We report a case of S. gallolyticus native valve endocarditis and spondylodiscitis in an 84-year old patient who finally died of an intracranial hemorrhage caused by an acute leukemia. We make a literature review, emphasizing the relative lack of references about S. gallolyticus in medical literature, and the need of updating the laboratory identification systems and clinicians work-up after the taxonomic changes for the so-called S. bovis.